The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)
نویسندگان
چکیده
منابع مشابه
Oligodendrocyte death, neuroinflammation, and the effects of minocycline in a rodent model of nonarteritic anterior ischemic optic neuropathy (rNAION)
Purpose Optic nerve (ON) damage following nonarteritic anterior ischemic optic neuropathy (NAION) and its models is associated with neurodegenerative inflammation. Minocycline is a tetracycline derivative antibiotic believed to exert a neuroprotective effect by selective alteration and activation of the neuroinflammatory response. We evaluated minocycline's post-induction ability to modify earl...
متن کاملSurgery for nonarteritic anterior ischemic optic neuropathy.
BACKGROUND Nonarteritic ischemic optic neuropathy is characterized by sudden and painless loss of vision in one eye, accompanied by pallid swelling of the optic disc. Although various medical interventions, such as corticosteroids and phenytoin sodium, have been used to treat nonarteritic ischemic optic neuropathy, no therapy has been proven effective. OBJECTIVES The objective of this review ...
متن کاملIncipient nonarteritic anterior ischemic optic neuropathy.
OBJECTIVE To describe the clinical entity of incipient nonarteritic anterior ischemic optic neuropathy (NAION). DESIGN Cohort study. PARTICIPANTS Fifty-four patients (60 eyes) seen in our clinic from 1973 through 2000. METHODS At their first visit to our clinic, all patients gave a detailed ophthalmic and medical history and underwent a comprehensive ophthalmic evaluation, color fundus ph...
متن کاملDendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy.
INTRODUCTION Polyamidoamine dendrimer nanoparticles (~ 4 nanometers) are inert polymers that can be linked to biologically active compounds. These dendrimers selectively target and accumulate in inflammatory cells upon systemic administration. Dendrimer-linked compounds enable sustained release of therapeutic compounds directly at the site of damage. The purpose of this study was to determine i...
متن کاملNonarteritic ischemic optic neuropathy.
BACKGROUND To describe the systemic and visual characteristics and prognosis in patients with nonarteritic ischemicoptic neuropathy (NAION) undergoing different treatments. METHODS Retrospective chart review was performed in Kaohsiung Veterans General Hospital patients from 1995-2005 with a clinical diagnosis of NAION, including nonarteritic anterior ischemic optic neuropathy and posterior is...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2016
ISSN: 1940-087X
DOI: 10.3791/54504